NOT KNOWN DETAILS ABOUT SAPLA

The purpose of SIK1 in tumorigenesis. SIK1 is often a tumor suppressor gene, which plays a very important regulatory job in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 also can ma